The current version of the Travel Time Matrix macro and the Reachable Points Filter macro do not support the Alteryx AMP engine.
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To disable the AMP engine, click on the workflow canvas to open the configuration settings, then go to the Runtime tab. At the bottom of the settings, untick the 'Use AMP Engine' option.
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For the Geocoder, Isochrones, and Routes macros, the Alteryx AMP Engine can be used without problems.